Lab Dept:

Chemistry

Test Name:

LAMOTRIGINE LEVEL

General Information

Lab Order Codes:

LAMO

Synonyms:

Lamictal

CPT Codes:

80175 – Lamotrigine

Test Includes:

Lamictal level reported in ug/mL.

Logistics

Test Indications:

Monitoring serum concentration of lamictal (lamotrigine), assessing compliance or adjusting lamotrigine dose in patients receiving other anticonvulsant drugs which interact pharmokinetically with lamictal (lamotrigine).

Lab Testing Sections:

Chemistry – St. Paul

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

4 hours, test performed daily

Special Instructions:

If this is a STAT order, please check with the provider to see if the specimen should be shipped immediately and performed STAT by the reference lab at an additional cost. If immediate shipment is necessary, please call the lab to make arrangements.

Specimen

Specimen Type:

Blood

Container:

Green (Lithium Heparin), no gel tube Alt: Red microtainer, no gel

Draw Volume:

0.6 mL blood

Processed Volume:

0.2 plasma/serum

Collection:

Routine venipuncture

 

Special Processing:

Lab Staff: Centrifuge specimen, remove aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens; sample clotted; collected in a gel tube

Interpretive

Reference Range:

2 – 20 ug/mL

Note: Current clinical information suggests the recommended concentrations for lamotrigine during chronic therapy are 2 - 20 ug/mL.

Critical Values:

N/A

Limitations:

Reporting Limit: 0.85 ug/mL

Methodology:

Immunoassay

References:

ARK, Lamotrigine Assay package insert, ARK Diagnostics, Inc, 1190 Bordeaux Drive, Sunnyvale, CA 94089 USA, Printed in USA, Revised October 2010, 1600-0179-00 Rev 02

ARK, Lamotrigine Calibrator package insert, ARK Diagnostics, Inc, 1190 Bordeaux Drive, Sunnyvale, CA 94089 USA, Printed in USA, Revised October 2010, 1600-0179-00 Rev 02

ARK, Lamotrigine Control package insert, ARK Diagnostics, Inc, 1190 Bordeaux Drive, Sunnyvale, CA 94089 USA, Printed in USA, Revised October 2010, 1600-0179-00 Rev 02

Making Sense of Lamotrigine Serum Levels (May 2005) Bassel W Abou-Khalil, MD, American Epilepsy Society, Epiepsy Currents, v.5(3), PMC1198624

Efficacy and Safety of Lamotrigine Monotherapy in Children and Adolescents with Epilepsy (March 2009) European Journal of Paediatric Neurology, Volume 13, Issue 2, pp 141-145

Updates:

3/22/2016: Testing moved from MedTox to internal test at Children’s