Factor replacement therapy may be necessary. Replacement therapy involves injecting a clotting factor concentrate into the blood via a vein. Clotting factor can be made from human plasma or can be genetically engineered (recombinant),
Replacement therapy can be provided on a regular basis to prevent bleeding (prophylactic therapy) or may be used only to stop bleeding after it has occurred (on-demand therapy). The infusions can be performed at home by the child or his family or through the infusion center. The clotting factor can be injected through a vein or through a surgically implanted port.
Other medications may be helpful in certain circumstances. Antifibrinolytic medicines such as Amicar help slow the breakdown of clots once they are formed. They are particularly useful in mucous membrane bleeding such as nosebleeds, mouth bleeding or intestinal bleeding. Desmopressin (DDAVP) is a man-made hormone, given by injection or nasal spray, that can sometimes be used to treat those with mild hemophilia A when they experience bleeding symptoms.