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Dexrazoxane (Zinecard)

Article Translations: (Spanish)

How does this medicine work?

Dexrazoxane (dex-rah-zox-ain) protects the heart from the effects of some specific chemotherapy medicines. It can also be used to stop some specific chemotherapy medicines from damaging healthy tissue if the port needle or IV needle becomes dislodged.

How is it given?

Dexrazoxane is given into the patient's central line (IV) immediately before specific chemotherapy medicines.

What are the side effects?


  • low blood cell counts
  • increased iron levels
  • decreased zinc levels


  • liver problems
  • pancreas problems
  • fever


  • nausea
  • vomiting
  • loss of appetite
  • feeling tired
  • diarrhea
  • hair loss

When should I call the doctor?

  • fever
  • bleeding
  • bruising
  • continued nausea and vomiting
  • continued diarrhea
  • irregular heartbeat
  • signs of allergic reaction:
    • rash or hives
    • wheezing
    • trouble breathing - call 911

What else do I need to know?

You and your child should know the names of all the medicines he or she is taking. Share this information with anyone involved in your child's care.

Check with the doctor, nurse practitioner, or pharmacist before giving any other prescription or non-prescription medicines, herbs, or vitamins.


This is not specific to your child but provides general information. If you have any questions, please call the oncology clinic or pharmacy.

Last reviewed by Hem/Onc 8/2015 

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This page is not specific to your child, but provides general information on the topic above. If you have any questions, please call your clinic. For more reading material about this and other health topics, please call or visit Children's Minnesota Family Resource Center library, or visit

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