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Tobramycin for Inhalation

How does this medicine work?

Tobramycin (toe bra MYE sin) for inhalation is an antibiotic used to treat bacteria in the lungs. It can also help prevent lung infections.

How should I give it?

  • Tobramycin for inhalation is inhaled using a nebulizer.
  • Tobramycin for inhalation is supplied in 4ml unit dose vials containing 300mg of tobramycin. Nebulization time for the 4ml dose is about 15 minutes.
  • The usual dose for adults and children is one vial (300mg) twice daily. Treatments should be as close to 12 hours apart as possible and not less than 6 hours apart. Tobramycin for inhalation may be used for 28 days followed by 28 days off.
  • Tobramycin for inhalation should not be diluted or mixed with any other medication. If other medications are to be nebulized, Tobramycin for inhalation should be the last one given.
  • Tobramycin for inhalation is supplied in foil pouches and should be stored in the refrigerator. Tobramycin for inhalation can be stored in the foil pouches (opened or unopened) at room temperature for up to 28 days.
  • Refrigerated Tobramycin for inhalation is clear or slightly yellow in color; unrefrigerated Tobramycin for inhalation may darken in color. This color change does not indicate any change in the quality of the medication.
  • Do not use Tobramycin for inhalation if it is cloudy or has particles in the solution.

It is recommended to do all therapy with reusable nebulizer that is designed for home use, and can be cleaned and sanitized on a daily basis.

What should I do if a dose is missed?

If a dose is missed, give it as soon as you remember, unless it is less than 6 hours until the next dose. In that case, skip the missed
dose and continue with the regular schedule. Never give a double dose.

What are the side effects?

Your child may have some side effects such as:

  • Ringing in the ears 
  • Voice changes (hoarseness)
  • Color changes in the saliva (spit)
  • Tiredness
  • Hearing loss

When should I call the clinic?

Patients with cystic fibrosis can have many symptoms. Some of these symptoms may be related to your medications. If you have new or worsening symptoms, tell your doctor.

What else do I need to know?

Learn the names and doses of all medicines he or she is taking. Share this information with anyone involved in your child's care.

Check the label and expiration date before giving each dose. Ask your pharmacist what to do with outdated or unused medicines.

Frequent hand hygiene is the most important way to prevent the spread of germs. Always wash hands well with soap for at least 15 seconds, and/or use an alcohol hand sanitizer, such as Purell®.


This sheet is not specific to your child, but provides general information. If you have any questions, please call your clinic.

Last reviewed 4/2020

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This page is not specific to your child, but provides general information on the topic above. If you have any questions, please call your clinic. For more reading material about this and other health topics, please call or visit Children's Minnesota Family Resource Center library, or visit

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