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Lenalidomide (Revlimid)

How does this medicine work?

Lenalidomide (leh-nuh-LIH-doh-mide) is a cancer medicine known as an immunomodulatory agent. It works by destroying or stopping the growth of cancer cells.

How is the medicine given?

Lenalidomide is given by mouth as a capsule. It should be taken at the same time each day. This can be taken with or without food. Lenalidomide should not be opened, crushed, broken, or chewed. If you or your child are unable to swallow capsules, please let your provider know.

What are the side effects?


  • Low blood cell counts
  • Fatigue
  • Itching


  • Skin rash
  • Constipation
  • Diarrhea
  • Fever
  • Decreased appetite
  • Muscle cramps


  • Blood clots
  • Liver and/or kidney changes

When should I call the clinic?

Call the clinic if:

  • Fever, chills
  • Bleeding, unusual bruising
  • Arm or leg swelling
  • Cough, shortness of breath, sore throat
  • Signs of an allergic reaction:

            - rash or hives

            - wheezing

            - trouble breathing - call 911

What else do I need to know?

If missed dose, if it has been less than 12 hours from the time the dose was due, you can give it. Do not give if it has been longer than 12 hours.

Lenalidomide can cause severe birth defects or death to an unborn baby. Even one capsule can cause serious harm. If you are pregnant or could become pregnant, DO NOT take or administer Lenalidomide without checking with your health care provider first. Males should NOT father a child while taking this medication. Before the healthcare provider prescribes Lenalidomide for you or your child, you will receive special written information about this drug and its ability to harm an unborn child.

Lenalidomide capsules contain lactose.

If you or your child misses a dose of Lenalidomide, if it has been less than 12 hours from the time the dose was due, you can give it. Do not give Lenalidomide if the missed dose has been longer than 12 hours.

You or your child will have regular blood tests while receiving this medication. This is to make sure all of the body’s organs are working properly.

You and your child should know the names of all the medicines he or she is taking. Share this information with anyone involved in your child’s care.

You or your child will need a new prescription each time this medication is filled. If you are a female, of child bearing age, you will need a pregnancy test before each prescription is written.

Store all medicines in their original container and away from direct sunlight or heat. Do not store in humid places such as the bathroom. Keep them out of children’s reach, locked up if possible.

If too much OR the wrong chemotherapy medicine is taken, call the oncology clinic right away. If your child is unconscious or has a seizure, call 911.


This sheet is not specific to your child but provides general information. If you have any questions, please call the oncology clinic or pharmacy.

 Reviewed by Hem/Onc 12/2016

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This page is not specific to your child, but provides general information on the topic above. If you have any questions, please call your clinic. For more reading material about this and other health topics, please call or visit Children's Minnesota Family Resource Center library, or visit

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