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Twin-twin transfusion syndrome (TTTS) procedure outcomes

TTTS + MWFCC

The Midwest Fetal Care Center (MWFCC) performed its first fetoscopic laser ablation (FLA) for twin-twin transfusion syndrome (TTTS) in 2008. Led by a team of top medical experts in the field of maternal-fetal medicine and fetal diagnosis and therapy, our program has become one of the highest volume treatment centers for TTTS in the nation and has exceptional outcomes.

Our center performed 251 laser surgeries between June 1, 2017, and December 10, 2025, with 242 delivered and 9 ongoing pregnancies, and an overall survival rate of 88%.

Surgical outcomes

A summary of Midwest Fetal Care Center’s current clinical outcomes data for the treatment of TTTS is presented here. Our goal is to provide our patients and community the latest TTTS patient outcomes data to support informed decision-making.

We are actively involved in research regarding TTTS and collaborate with other advanced fetal care centers in the U.S. and internationally through the North American Fetal Therapy network (NAFTnet) and the International Fetal Medicine Surgery Society (IFMSS). We submit patient data (with informed consent) to a multi-center collaborative registry hosted by NAFTnet to investigate outcomes of this procedure with the goal of advancing care of families affected by TTTS.

TTTS stage and gestational age at time of FLA

Pie chart. Stage 1: 14%, Stage 2: 33%, Stage 3: 44%, Stage 4: 5%, and TAPS: 4%.
Pie chart. Stage 1: 14%, stage 2: 33%, Stage 3: 44%, Stage 4: 5%, TAPS: 4%.

Average estimated gestational age at FLA: 20 weeks, 3 days
Average estimated gestational age at delivery: 31 weeks, 1 day

Treatment Summary

96%

of procedures resulted in one or both twin(s) surviving

79%

of procedures resulted in both twins surviving

Neonatal survival after TTTS fetal procedure

FLA 415 out of 473 total babies delivered

pie chart. 0 survivors: 4%, 1 survivor: 17%, 2 survivors: 79%.

Includes 9 triplet cases delivered: 7 cases with 3 survivors, 2 cases with 2 survivors.

Neonatal survival rate by TTTS stage

2026_updates_30 day post-delivery NICU survival rate by TTTS stage

Data measured July 1, 2017 – December 10, 2025

We encourage you to reach out to other health care systems to request and review their outcomes data in order to utilize the information available when evaluating your health care options.

See our other outcomes

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