Children’s Minnesota has created a number of clinical practice guidelines for health professionals that highlight an evidence-based approach to the management of certain conditions in order to reduce unwarranted variation in care.
Guidelines are designed to apply to the bulk of patients with a given condition and should be adapted to individual patients based upon clinical judgment and individual situations. To assist providers with real-time decision making, most of the clinical guidelines at Children’s Minnesota consist of visual treatment algorithms/pathways, evidence-based ordersets, bibliographies and any applicable rules/alerts embedded within the electronic health record. In addition to clinical guidelines in pdf format listed below, more than 25 of the Children’s Minnesota clinical guidelines are available in interactive digital format through an avoMD guidelines application, which is accessible for providers on internal platforms and mobile devices.
Clinical guidelines
Acetaminophen poisoning
Acetaminophen poisoning guideline
Adnexal/ovarian torsion
Agitation
Pharmacologic Management of Agitation Guideline
Allergy/anaphylaxis
Anaphylaxis guideline
Beta-lactam allergy guideline
Anemia
Anemia in patients with heavy menstruation
Iron Deficiency Anemia in Patients ≤ 5 Years Old
Iron Infusion Reaction Clinical Practice Guideline
Appendicitis
Appendicitis: ED and inpatient/surgical guideline
Asthma
Asthma exacerbation ED/inpatient guideline
Asthma outpatient guideline
Blunt cerebrovascular injury screening-trauma
Blunt cerebrovascular injury (BCVI) screening guideline
Brief resolved unexplained event (BRUE)
Brief resolved unexplained event (BRUE) guideline
Bronchiolitis
Button battery ingestion
Cannabinoid hyperemesis syndrome
Cannabinoid hyperemesis syndrome guidelineCardiac rehabilitation
Cardiac rehabilitation guidelineCervical spine clearance
Cervical spine clearance guidelineChylothorax
Post-Operative Chylothorax Management GuidelineCongenital CMV guideline
Congenital CMV guidelineClostridioides difficile infection (CDI)
C. difficile testing guideline C. difficile treatment algorithm COVID-19 (Coronavirus) interim guidelines
Coronavirus Interim Guidelines have not been through the formal guideline governance council review process but have been approved for interim use by clinical leaders. They should be viewed as interim guidelines and will be updated frequently as the situation evolves. Health care providers should also refer to external sources such as CDC.gov and the Minnesota Department of Health for additional resources for this dynamic situation.
Diagnostic testing strategy
Medical management for patients with confirmed COVID-19
Suspected MIS-C management recommendations
VTE prophylaxis in COVID-19 patients – see below under VTE risk stratification in hospitalized patients (includes patients with COVID-19)
Paxlovid prescribing process
Croup
Croup guideline: age 3 months-8 yearsFever ≥ 38.0°C (100.4°F) without obvious source (infant 1-60 Days)
Febrile infant ED/inpatient guideline
Fever and neutropenia
H-Pylori
H Pylori guidelineHigh flow nasal cannula
High flow nasal cannula guidelineHypothermia, accidental – trauma
Accidental primary hypothermia (HT) guidelineIntussusception
Jaundice
Kawasaki disease
Suspected kidney stone
MASLD primary care
Metabolic dysfunction-associated steatotic liver disease guideline
Measles
Meningitis
Menstrual bleeding
Anemia in patients with heavy menstruation
Musculoskeletal (MSK) Infection (Osteomyelitis, Septic Arthritis, or Deep Pyomyositis)
Nasogastric (NG) tube
Nasogastric (NG) tube discharge planning guidelineNeonatal (NICU)
Apnea of prematurityCPG – Gestational Age-Based Feeding
Neurogenic bladder and bowel
Neurogenic bladder guidelinesNeurogenic bowel guidelines
Nothing by mouth (NPO)
Nothing by mouth (NPO) hospital guidelineOpen fracture – trauma
Antibiotic prophylaxis in patients with open fractures
Opioid withdrawal guideline
Otitis media
Penicillin allergy delabeling
Penicillin allergy delabeling guideline
Pharmacy
Key potentially inappropriate drugs in pediatrics: The kids list
Pneumonia
Community acquired pneumonia guideline
Pneumonia complicated by empyema inpatient guideline
Post-op thyroidectomy management
Post-op thyroidectomy management guideline
Pneumothorax
Primary spontaneous pneumothorax (PSP) guideline
Preseptal/orbital cellulitis
Preseptal/orbital cellulitis guideline
Psychosis
Acute Psychosis Guideline (First Episode)
Pyloric Stenosis
Sedation
Post Sedation Infant Monitoring
Seizure and status epilepticus
Febrile seizure guideline
Pediatric Seizure Prophylaxis for Head Injuries – Trauma
Seizure and status epilepticus guideline
Sepsis
Sexually Transmitted Infections
Expedited Partner Therapy for Sexually Transmitted Infections
Sexually Transmitted Infection Screening Guideline for Asymptomatic Patients
Sickle cell
Sickle cell vaso-occlusive pain episode management guideline
Suspected shunt malfunction or infection
Suspected shunt malfunction or infection ED guideline
Skin and soft tissue infections (SSTIs)
Skin and soft tissue infections guideline
Solid organ injury – trauma
Solid organ injury management guideline
Speaking and swallowing valve (Passy-Muir)
Speaking and swallowing valve (Passy-Muir) guideline: Inline valve trial
Stroke
Cerebral venous sinus thrombosis CVST guideline
ED suspected stroke guideline
Inpatient suspected stroke guideline
Surgical antibiotic prophylaxis
Testicular torsion
Evaluation of potential testicular torsion guideline
Thrombocytopenia
Acute immune thrombocytopenia (ITP) guideline
Tonsillectomy
Post-tonsillectomy hemorrhage
Tonsillectomy +/- adenoidectomy
