24/7 referral, consult, admission and neonatal transport assistance.

Patient education

Provide your patients with reliable information about conditions and illnesses.

Children’s Minnesota has created a number of clinical practice guidelines for health professionals that highlight an evidence-based approach to the management of certain conditions in order to reduce unwarranted variation in care.

Guidelines are designed to apply to the bulk of patients with a given condition and should be adapted to individual patients based upon clinical judgment and individual situations. To assist providers with real-time decision making, most of the clinical guidelines at Children’s Minnesota consist of visual treatment algorithms/pathways, evidence-based ordersets, bibliographies and any applicable rules/alerts embedded within the electronic health record.


Appendicitis ED Guideline
Appendicitis Surgical Guideline


Asthma Exacerbation ED/Inpatient Guideline

Brief Resolved Unexplained Event (BRUE)

Brief Resolved Unexplained Event (BRUE) Guideline


Bronchiolitis Guideline

Cardiac Rehabilitation

Cardiac Rehabilitation Guideline

Cervical Spine Clearance

Cervical Spine Clearance Guideline

Clostridioides Difficile Infection (CDI)

C. Difficile Testing Guideline
C. Difficile Treatment Algorithm

COVID-19 (Coronavirus) Interim Guidelines

Coronavirus Interim Guidelines have not been through the formal guideline governance council review process but have been approved for interim use by clinical leaders. They should be viewed as interim guidelines and will be updated frequently as the situation evolves. Health care providers should also refer to external sources such as CDC.gov and the Minnesota Department of Health for additional resources for this dynamic situation.

Diagnostic testing strategy
Medical Management for patients with confirmed COVID-19
Suspected MIS-C management recommendations
Testing Algorithm: ED/Ambulatory
VTE Prophylaxis in COVID-19 patients


Croup Guideline: Age 3 Months-8 Years


Diabetic Ketoacidosis (DKA) Guideline
Diabetes DKA Overnight Admission St. Paul Housestaff Guideline

Fever ≥ 38.0°C (100.4°F) Without Obvious Source (Infant 1-60 Days)

Febrile Infant ED/Inpatient Guideline

Fever and Neutropenia

Fever and Neutropenia Treatment Guideline


Acute Gastroenteritis Inpatient Guideline
Oral Rehydration Therapy – Less than 10kg Hmong, Somali, Spanish
Oral Rehydration Therapy – More than 10kg Hmong, Somali, Spanish


Hyperbilirubinemia in Newborn Infants ED Guideline

Kawasaki Disease

Classic Kawasaki Disease Guideline

Suspected Kidney Stone

Suspected Kidney Stone

Lab Guidelines

Clostridioides Difficile Infection (C-Diff) Testing Guideline


Measles Management Guideline

Menstrual Bleeding

Adolescent Symptomatic Acute Menstrual Bleeding – ED/Inpatient Guideline

Musculoskeletal (MSK)

Musculoskeletal (MSK) Infection Guideline

Nasal Brindle

Nasal Brindle (NB), Securement Device for NG/NJ Discharge Guideline

Neurogenic Bladder and Bowel

Neurogenic Bladder Guidelines
Neurogenic Bowel Guidelines

Open Fracture – Trauma

Antibiotic Prophylaxis in Patients with Open Fractures


Key potentially inappropriate drugs in pediatrics: The Kids List


Community Acquired Pneumonia Inpatient Guideline
Pneumonia Complicated by Empyema Inpatient Guideline


Primary Spontaneous Pneumothorax (PSP) Guideline


New Tracheostomy Recovery/Rehabilitation in PICU Guideline

Suspected Shunt Malfunction or Infection

Suspected Shunt Malfunction or Infection ED Guideline

Skin and Soft Tissue Infections (SSTIs)

Skin and Soft Tissue Infections Guideline

Speaking and Swallowing Valve (Passy-Muir)

Speaking and Swallowing Valve (Passy-Muir) Guideline: Inline Valve Trial


ED Suspected Stroke

Surgical Antibiotic Prophylaxis

Comprehensive Surgical Antibiotic Prophylaxis Guideline

Testicular Torsion

Evaluation of Potential Testicular Torsion Guideline

Urinary Tract Infections (UTI)

Urinary Tract Infections Guideline

Venous Thromboembolism (VTE)

VTE Prophylaxis in Trauma Patients (>12 years)
VTE Risk Stratification in Hospitalized Patients

Guidelines are updated periodically in keeping with emerging evidence. Each guideline contains an important disclaimer and users must proceed at their own risk accordingly: This guideline is designed for general use with most patients; each clinician should use his or her own independent judgment to meet the needs of each individual patient. This guideline is not a substitute for professional medical advice, diagnosis or treatment.

For more information, email [email protected].