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Patient education

Provide your patients with reliable information about conditions and illnesses.

Children’s Minnesota has created a number of clinical practice guidelines for health professionals that highlight an evidence-based approach to the management of certain conditions in order to reduce unwarranted variation in care.

Guidelines are designed to apply to the bulk of patients with a given condition and should be adapted to individual patients based upon clinical judgment and individual situations. To assist providers with real-time decision making, most of the clinical guidelines at Children’s Minnesota consist of visual treatment algorithms/pathways, evidence-based ordersets, bibliographies and any applicable rules/alerts embedded within the electronic health record. In addition to clinical guidelines in pdf format listed below, more than 25 of the Children’s Minnesota clinical guidelines are available in interactive digital format through an avoMD guidelines application, which is accessible for providers on internal platforms and mobile devices.

Adnexal/Ovarian Torsion

Adnexal/Ovarian Torsion


Anaphylaxis Guideline
Beta-Lactam Allergy Guideline


Adolescent with Anemia and Historic or Current Heavy Menstrual Bleeding
Iron Deficiency Anemia in Patients ≤ 5 Years Old


Appendicitis ED Guideline
Appendicitis Inpatient/Surgical Guideline


Asthma Exacerbation ED/Inpatient Guideline
Asthma Outpatient Guideline

Brief Resolved Unexplained Event (BRUE)

Brief Resolved Unexplained Event (BRUE) Guideline


Bronchiolitis Guideline

Button Battery Ingestion

Button Battery Guideline

Cannabinoid Hyperemesis Syndrome

Cannabinoid Hyperemesis Syndrome Guideline

Cardiac Rehabilitation

Cardiac Rehabilitation Guideline

Cervical Spine Clearance

Cervical Spine Clearance Guideline

Congenital CMV Guideline

Congenital CMV Guideline

Clostridioides Difficile Infection (CDI)

C. Difficile Testing Guideline
C. Difficile Treatment Algorithm

COVID-19 (Coronavirus) Interim Guidelines

Coronavirus Interim Guidelines have not been through the formal guideline governance council review process but have been approved for interim use by clinical leaders. They should be viewed as interim guidelines and will be updated frequently as the situation evolves. Health care providers should also refer to external sources such as and the Minnesota Department of Health for additional resources for this dynamic situation.

Medical Management for patients with confirmed COVID-19
Suspected MIS-C management recommendations
VTE Prophylaxis in COVID-19 patients – see below under VTE Risk Stratification in Hospitalized Patients (includes Patients with COVID)


Croup Guideline: Age 3 Months-8 Years


Diabetic Ketoacidosis (DKA) Guideline
Diabetes DKA Inpatient Guideline


Pneumonia Complicated by Empyema Inpatient Guideline

Expedited Partner Therapy for Sexually Transmitted Infections

EPT Clinical Guideline

Fever ≥ 38.0°C (100.4°F) Without Obvious Source (Infant 1-60 Days)

Febrile Infant ED/Inpatient Guideline

Fever and Neutropenia

Fever and Neutropenia Treatment Guideline


Acute Gastroenteritis Inpatient Guideline
Oral Rehydration Therapy – Less than 10kg Hmong, Somali, Spanish
Oral Rehydration Therapy – More than 10kg Hmong, Somali, Spanish

High Flow Nasal Cannula

High Flow Nasal Cannula Guideline

Hypothermia, Accidental – Trauma

Accidental Primary Hypothermia (HT) Guideline


Intussusception ED Clinical Guideline


Hyperbilirubinemia Guideline

Kawasaki Disease

Kawasaki Disease Guideline

Suspected Kidney Stone

Suspected Kidney Stone

Lab Guidelines

Clostridioides Difficile Infection (C-Diff) Testing Guideline

MASLD Primary Care

Metabolic Dysfunction-Associated Steatotic Liver Disease Guideline


Measles Management Guideline


Meningitis Guideline

Menstrual Bleeding

Adolescent with Anemia and Historic or Current Heavy Menstrual Bleeding

Musculoskeletal (MSK)

Musculoskeletal (MSK) Infection Guideline

Neurogenic Bladder and Bowel

Neurogenic Bladder Guidelines
Neurogenic Bowel Guidelines

Nothing by Mouth (NPO)

Nothing by Mouth (NPO) Hospital Guideline

Open Fracture – Trauma

Antibiotic Prophylaxis in Patients with Open Fractures

Opioid Withdrawal Guideline

Opioid Withdrawal Guideline

Otitis Media

Otitis Media Guideline

Penicillin Allergy Delabeling

Penicillin Allergy Delabeling Guideline


Key potentially inappropriate drugs in pediatrics: The Kids List


Community Acquired Pneumonia Inpatient Guideline
Pneumonia Complicated by Empyema Inpatient Guideline

Post-op Thyroidectomy Management

Post-op Thyroidectomy Management Guideline


Primary Spontaneous Pneumothorax (PSP) Guideline

Preseptal/Orbital Cellulitis

Preseptal/Orbital Cellulitis Guideline


New Tracheostomy Recovery/Rehabilitation in PICU Guideline

Seizure and Status Epilepticus

Seizure and Status Epilepticus Guideline

Sepsis Guideline

Sepsis Guideline

Suspected Shunt Malfunction or Infection

Suspected Shunt Malfunction or Infection ED Guideline

Skin and Soft Tissue Infections (SSTIs)

Skin and Soft Tissue Infections Guideline

Solid Organ Injury – Trauma

Solid Organ Injury Management Guideline

Speaking and Swallowing Valve (Passy-Muir)

Speaking and Swallowing Valve (Passy-Muir) Guideline: Inline Valve Trial


Cerebral Venous Sinus Thrombosis CVST Guideline
ED Suspected Stroke Guideline
Inpatient Suspected Stroke Guideline

Surgical Antibiotic Prophylaxis

Comprehensive Surgical Antibiotic Prophylaxis Guideline

Testicular Torsion

Evaluation of Potential Testicular Torsion Guideline


Post-tonsillectomy Hemorrhage
Tonsillectomy +/- Adenoidectomy

Transfusion Pre-medication

Transfusion Pre-medication Hospital Guideline

Urinary Tract Infections (UTI)

Urinary Tract Infections Guideline

Venous Thromboembolism (VTE)

VTE Prophylaxis in Trauma Patients (>12 years)
VTE Risk Stratification in Hospitalized Patients (includes Patients with COVID)

Guidelines are updated periodically in keeping with emerging evidence. Each guideline contains an important disclaimer and users must proceed at their own risk accordingly: This guideline is designed for general use with most patients; each clinician should use his or her own independent judgment to meet the needs of each individual patient. This guideline is not a substitute for professional medical advice, diagnosis or treatment.

For more information, email [email protected].