Patient & Family Education Materials

Start over with a New Search

Dornase Alfa (Pulmozyme)

What is Pulmozyme?

Dornase Alpha (DOOR nase AL fa) or Pulmozyme thins the mucus in your lungs. This makes it easier to breathe and helps
prevent lung infections.

How should I give it?

  • Pulmozyme is inhaled using a nebulizer.
  • Pulmozyme comes in 2.5ml unit dose vials containing 2.5mg of dornase alpha.
  • Pulmozyme should be refrigerated and protected from light until ready to use.
  • Pulmozyme is only good for 24 hours if left at room temperature.
  • Pulmozyme should not be shaken.
  • 2.5mg Pulmozyme is given either once a day or twice a day.
  • Pulmozyme should not be diluted or mixed with other medications.
  • Do not use Pulmozyme if the solution is cloudy, discolored or left at room temperature for 24 hours.
  • Pulmozyme should be given after a nebulized bronchodilator (such as albuterol) and before inhaled antibiotics (such as TOBI) if ordered.

It is recommended to do all therapy with reusable nebulizer that is designed for home use, and can be cleaned and sanitized on a daily basis.

What should I do if a dose is missed?

If a dose is missed, give it as soon as you remember. Never give a double dose.

What are the side effects?

Your child may have some side effects such as:

  • Voice changes (hoarseness)
  • Sore throat
  • Chest pain
  • Red watery eyes
  • Fever
  • Headache
  • Tiredness
  • Increased cough

These side effects are usually mild and temporary.

What else do I need to know?

Learn the names and doses of all medicines he or she is taking. Share this information with anyone involved in your child's care.

Check the label and expiration date before giving each dose. Ask your pharmacist what to do with outdated or unused medicines. If there is no "take-back" program:

  1. Empty the medicine into a leak-proof container.
  2. Add coffee grounds, dirt, flour, kitty litter, salt, or other substance.
  3. Put on the lid and throw it in the trash.

Frequent hand hygiene is the most important way to prevent the spread of germs. Always wash hands well with soap for at least 15 seconds, and/or use an alcohol hand sanitizer, such as Purell®.


This is not specific to your child, but provides general information. If you have any questions, please call your clinic.

Last reviewed 8/2015 

Back To Top

This page is not specific to your child, but provides general information on the topic above. If you have any questions, please call your clinic. For more reading material about this and other health topics, please call or visit Children's Minnesota Family Resource Center library, or visit

© 2024 Children's Minnesota