Pazopanib (Votrient)

How does this medicine work?

Pazopanib (puh-ZOH-puh-nib) is a cancer medicine known as a tyrosine kinase inhibitor. It works to destroy cancer cells by blocking the proteins of the cell.

How is the medicine given?

Pazopanib is given by mouth as a capsule. It should be taken at the same time each day. Take your dose of pazopanib each day either 1 hour before or 2 hours after you eat with about 8 ounces (240 mL) of water. You will take the tablets as instructed by your provider. You should swallow the tablets whole. Do not chew, crush, or break the tablets If you or your child are unable to swallow capsules, please let your provider know.

What are the side effects?

Common

• Low blood cell counts
• Fatigue
• Nausea
• Vomiting

Occasional 

• High blood pressure
• High blood sugar
• Pain in extremities
• Rash
• Decreased appetite
• Dizziness
• Headache
• Protein in urine
• Sores in mouth
• Changes in hair color
• Decreased thyroid function

Rare              

• Stomach and intestine changes
• Liver and/or kidney changes
• Blood clots
• Heart changes

When should I call the clinic?

Call the clinic if:

• Fever, chills
• Bleeding, unusual bruising
• Arm/leg swelling
• Confusion, vision changes, seizures
• Cough, shortness of breath, sore throat
• Signs of an allergic reaction:

            - rash or hives

            - wheezing

            - trouble breathing - call 911

What else do I need to know?

Pazopanib should be stopped at least 7 days prior to any surgery. Discuss with your provider when to restart the medication.

If a dose is missed, do not take or “make up” the dose unless there are at least 12 hours until the next scheduled dose.

If you vomit within 30 minutes of taking the dose, the dose may be repeated. If more than 30 minutes have elapsed, do not repeat the dose.

Do not drink grapefruit juice or eat grapefruit while taking Pazopanib. Certain medications can increase the side effects of Pazopanib. Please talk with your healthcare provider before starting any new prescription or nonprescription medications, herbal products, or supplements.

All caregivers should wear gloves when handling urine, stool, and vomit while your child is receiving chemotherapy and for 48 hours afterward. Urine, stool, and vomit can be safely disposed of in septic tanks and the sewer system.

You or your child will have regular blood tests while receiving this medication. This is to make sure all of the body’s organs are working properly.

You and your child should know the names of all the medicines he or she is taking. Share this information with anyone involved in your child’s care.

Store all medicines in their original container and away from direct sunlight or heat. Do not store in humid places such as the bathroom. Keep them out of children’s reach, locked up if possible.

If too much OR the wrong chemotherapy medicine is taken, call the oncology clinic right away. If your child is unconscious or has a seizure, call 911.

Questions?

This is not specific to your child but provides general information. If you have any questions, please call the oncology clinic or pharmacy.

Reviewed by Hem/Onc 12/2016

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