Seizure Rescue Medication - Buccal Administration

Article Translations: (Spanish) (Somali)

How does this medicine work? 

Buccal medication administration is a liquid medication given in the cheeks by a syringe. The Buccal (cheek) route is often used to stop seizures that will not stop on their own, or as a “rescue.” The medication starts working to stop the seizure within 10 minutes of administration.

How should I give it? 

Buccal rescue medications come in liquid form. Give the medication per your provider’s order.

To give the buccal rescue medication:

1. Obtain the medication, draw up the medication to ordered dose in an oral syringe, if it is not already pre-drawn up 
2. Assist your child into a seated or side-lying position if sitting is not appropriate for their condition 
3. Insert the oral syringe into the lower cheek of your child’s mouth by pulling the lower lip down. DO NOT force or hold open their mouth. 
4. Slowly give the medication (no more than 2 ml in each cheek), ensuring the tip of the syringe is placed directly into the lower cheek surface so that the medication can be absorbed in the mucous membranes (gums). 
5. It is likely that a portion of the medication may be swallowed by your child. Encourage them, if possible, to not swallow the medication.  

• If a second dose is needed (as prescribed by your doctor), give the second dose. 
• Do not give more than two doses. Call your doctor or go to the emergency room if more than 2 doses are required. 
• If seizure does not stop after the buccal medication is used, get emergency help right away. 

Are there any precautions to take with food or other medicines? 

Common buccal seizure rescue medications are Diazepam or Midazolam. Both Diazepam and Midazolam are benzodiazepine medicines. Benzodiazepine medicines slow down activity in the brain and nervous system, known as depressants. Taking benzodiazepines with opioid medicine, alcohol or other central nervous system medication depressants can cause severe drowsiness and breathing problems. Talk with your provider about recommendations for use. 

What should I do if a dose is missed? 

This drug is used on a needed basis. Do not use it more often than told by a provider.  

What are the side effects? 

• Feeling sleepy 
• Feeling tired or weak 
• Muscle weakness 

Questions? 

This information is not specific to your child but provides general information. If you have any questions, please call your clinic.  

Reviewed 8/2025

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